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Chemistry

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Development of a Chemoproteomic Approach to Study Kinase-Substrate Interactions and the Discovery of CDK4 as a 4E-BP1 Kinase

颁布单位：[University of Michigan] | 颁布时间：2019 | 实施时间：2019 | 学科分类：[Kinase, Chemoproteomics, Cap-dependent Translation, CDK4, Cell Cycle, Biological Chemistry, Molecular, Cellular and Developmental Biology, Chemistry, Science (General), Health Sciences, Science, Chemical Biology]

预览 | 原文链接 [浏览：28 下载：8]
A Two-Prong Approach for Targeting the mRNA Cap-Dependent Translation Initiation: Small Molecules and Hydrocarbon Stapled Peptides

颁布单位：[University of Michigan] | 颁布时间：2018 | 实施时间：2018 | 学科分类：[drug discovery high throughput screening, protein-protein interaction assay development, chemical biology, cap-dependent translation initiation, hydrocarbon stapled peptides targeting eIF4E interactions, protein-protein interactions, Astronomy, Atmospheric, Oceanic and Space Sciences, Biological Chemistry, Chemical Engineering, Chemistry, Science, Chemical Biology]

预览 | 原文链接 [浏览：16 下载：2]
Structural Studies and Pharmacological Targeting of Protein Kinases in Obesity and Heart Disease

颁布单位：[University of Michigan] | 颁布时间：2018 | 实施时间：2018 | 学科分类：[Kinase, X-ray crystallography, Adrenergic receptor signaling, Structure-based drug design, Biological Chemistry, Chemistry, Molecular, Cellular and Developmental Biology, Science, Chemical Biology]

预览 | 原文链接 [浏览：38 下载：11]
Adaptation of Chemical Biology Approaches for Dissecting Disordered Protein Dynamics

颁布单位：[University of Michigan] | 颁布时间：2018 | 实施时间：2018 | 学科分类：[IDP, Intrinsically Disordered Proteins, Protein Dynamics, Chemistry, Science, Chemical Biology]

预览 | 原文链接 [浏览：17 下载：29]
Dissecting Transcriptional Coactivator Binding Networks To Enable Small Molecule Modulation

颁布单位：[University of Michigan] | 颁布时间：2017 | 实施时间：2017 | 学科分类：[chemical biology, protein protein interactions, transcription, peptides, drug discovery, Chemistry, Science, Chemical Biology]

预览 | 原文链接 [浏览：21 下载：10]
Mechanistic Investigation of the Transcriptional Coactivator Med25 and its Protein-Protein Interaction Network

颁布单位：[University of Michigan] | 颁布时间：2017 | 实施时间：2017 | 学科分类：[Med25 AcID, Transcriptional protein-protein interactions, Natural products, protein-observed fluorine NMR, Chemical Biology, Chemistry, Science, Chemical Biology]

预览 | 原文链接 [浏览：29 下载：2]
Structure and Biochemistry of Cytochromes P450 Involved in the Biosynthesis of Macrolide Antibiotics

颁布单位：[University of Michigan] | 颁布时间：2017 | 实施时间：2017 | 学科分类：[Cytochrome P450, Macrolide antibiotics, Natural products, Biosynthesis, Biological Chemistry, Chemistry, Science, Chemical Biology]

预览 | 原文链接 [浏览：24 下载：3]
Targeting the Activator Interaction Domain of Mediator Subunit Med25.

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[Protein-protein interactions, Chemical Biology, High-throughput screening, Natural Products, Transcription, Biological Chemistry, Chemistry, Science, Chemistry]

预览 | 原文链接 [浏览：38 下载：99]
Chemical Tools to Interrogate Protein Sulfenylation by Fluorescence Microscopy and NMR.

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[Fluorescent probe, Bioconjugation, Cysteine redox chemistry and biology, 19F fluorine NMR probes, Chemical switch, Live-cell imaging, Chemistry, Science, Chemical Biology]

预览 | 原文链接 [浏览：22 下载：11]
De Novo Designed Metallopeptides to Investigate Metal Ion Homeostasis, Electron Transfer, and Redox Catalysis.

颁布单位：[University of Michigan] | 颁布时间：2015 | 实施时间：2015 | 学科分类：[metal homeostasis, electron transfer protein, laser flash photolysis, tyrosine radical, nitrite reductase, Chemistry, Science, Chemical Biology]

预览 | 原文链接 [浏览：48 下载：0]