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Medicinal Chemistry

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Development of Novel Anticancer Therapeutics: Total Synthesis of Lactimidomycin and its Analogs and Synthetic Strategies Towards Diterpene Natural Products.

颁布单位：[University of Michigan] | 颁布时间：2015 | 实施时间：2015 | 学科分类：[Organic Chemistry, Medicinal Chemistry, Lactimidomycin, Total Synthesis of Natural Products, Diterpene-Based Small Molecules, Anticancer Therapeutics, Chemistry, Science (General), Science, Chemistry]

预览 | 原文链接 [浏览：104 下载：61]
Synthesis and Biochemical Evaluation of Multifunctional Acetylcholinesterase Inhibitor Hybrids for Treatment of Alzheimer's Disease.

颁布单位：[University of Michigan] | 颁布时间：2014 | 实施时间：2014 | 学科分类：[Alzheimer", s Disease, Acetylcholinesterase, Amyloid-beta, Tacrine, Mefenamic Acid, Multifunctional Molecules, Biological Chemistry, Neurosciences, Pharmacy and Pharmacology, Chemistry, Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：84 下载：20]
Positron Emission Tomography Radiochemistry: Improved Methodology and a Novel PET Imaging Agent for the Dopamine D3 Receptor

颁布单位：[University of Michigan] | 颁布时间：2017 | 实施时间：2017 | 学科分类：[Positron Emission Tomography, Radiochemistry, Fluorine-18, Dopamine Receptors, D3 Receptors, Green Chemistry, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：78 下载：2]
Developing a Bacterial P450 as a General and Regioselective Catalyst for C-H Bond Oxidation.

颁布单位：[University of Michigan] | 颁布时间：2014 | 实施时间：2014 | 学科分类：[C-H Functionalization, Bio-catalysis, Organic Synthesis, Enzymes, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：67 下载：31]
Type I Polyketide Synthases:Methodology, Biocatalysis, and Evaluation of Substrate Promiscuity.

颁布单位：[University of Michigan] | 颁布时间：2015 | 实施时间：2015 | 学科分类：[polyketide synthases, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：42 下载：16]
Development of a Novel Class of Multifunctional Virulence-Attenuating Antibiotics.

颁布单位：[University of Michigan] | 颁布时间：2013 | 实施时间：2013 | 学科分类：[Antibiotics, Group a Streptococcus, Structure Activity Relationship, Macromolecular Target Identification, Biofilm Inhibition, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：41 下载：2]
SMARTS Approach to Chemical Data Mining and Physicochemical PropertyPrediction.

颁布单位：[University of Michigan] | 颁布时间：2009 | 实施时间：2009 | 学科分类：[Cheminformatics, Chemoinformatics, Chemical Data Mining, Physicochemical Property Prediction, Chemical Spaces, Drug Discovery, Computer Science, Pharmacy and Pharmacology, Chemistry, Science (General), Engineering, Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：39 下载：35]
Synthesis and Evaluation of GAT-1 Selective PET Probes

颁布单位：[University of Michigan] | 颁布时间：2018 | 实施时间：2018 | 学科分类：[GABA, transporter, medicinal chemistry, fluorine-18, positron emission tomography, neuroimaging, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：38 下载：21]
Design, Synthesis and Biological Evaluation of Non-Peptidic Small Molecular SMAC Mimetics as Potent IAP Inhibitors.

颁布单位：[University of Michigan] | 颁布时间：2008 | 实施时间：2008 | 学科分类：[Smac, XIAP, C-IAP1, C-IAP2, Apoptosis, Cancer, Chemistry, Oncology and Hematology, Pharmacy and Pharmacology, Science (General), Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：36 下载：21]
Synthesis and Evaluation of Mixed Efficacy Mu Opioid Receptor (MOR), Delta Opioid Receptor (DOR) Peptidomimetic Ligands.

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[Opioid, Peptidomimetic, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：35 下载：21]