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Health Sciences

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Development of a Chemoproteomic Approach to Study Kinase-Substrate Interactions and the Discovery of CDK4 as a 4E-BP1 Kinase

颁布单位：[University of Michigan] | 颁布时间：2019 | 实施时间：2019 | 学科分类：[Kinase, Chemoproteomics, Cap-dependent Translation, CDK4, Cell Cycle, Biological Chemistry, Molecular, Cellular and Developmental Biology, Chemistry, Science (General), Health Sciences, Science, Chemical Biology]

预览 | 原文链接 [浏览：28 下载：8]
Methodological Advances for Drug Discovery and ProteinEngineering

颁布单位：[University of Michigan] | 颁布时间：2018 | 实施时间：2018 | 学科分类：[drug discovery, protein engineering, protein-ligand docking, free energy calculation, machine learning, statistics, Biomedical Engineering, Chemical Engineering, Pharmacy and Pharmacology, Chemistry, Ecology and Evolutionary Biology, Physics, Statistics and Numeric Data, Engineering, Health Sciences, Science, Bioinformatics]

预览 | 原文链接 [浏览：34 下载：18]
The Function of the ASH1L Histone Methyltransferase in Cancer: A Chemical Biology Approach

颁布单位：[University of Michigan] | 颁布时间：2018 | 实施时间：2018 | 学科分类：[drug development, histone methyltransferase, leukemia, fragment-based drug discovery, Biological Chemistry, Medicine (General), Oncology and Hematology, Pathology, Pharmacy and Pharmacology, Chemistry, Science (General), Health Sciences, Science, Molecular & Cellular Path PhD]

预览 | 原文链接 [浏览：20 下载：6]
Development, Synthesis, and Characterization of G Protein-Coupled Receptor Kinase Inhibitors Using Structure Based Drug Design for the Advancement of Heart Failure Therapeutics

颁布单位：[University of Michigan] | 颁布时间：2017 | 实施时间：2017 | 学科分类：[Medicinal Chemistry, GRK Inhibitors, Heart Failure Therapeutics, G-protein couple receptor kinases, Structural Biology, Biological Chemistry, Pharmacy and Pharmacology, Chemistry, Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：15 下载：8]
Disruption of Endosomal Membrane by Cationic Vectors Drives Endosomal Release and Enables Successful Gene Delivery

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[Gene delivery, Gene therapy, Endosomal escape, Drug delivery, Proton sponge, siRNA delivery, Biomedical Engineering, Biological Chemistry, Chemistry, Science (General), Engineering, Health Sciences, Science, Biomedical Engineering]

预览 | 原文链接 [浏览：22 下载：16]
An Antibiotic Discovery Campaign Targeting VirF, the Main Transcriptional Regulator of Virulence in Shigella flexneri

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[Antibiotic Discovery Campaign, Shigella, Anti-virulence, VirF, Biological Chemistry, Microbiology and Immunology, Pharmacy and Pharmacology, Chemistry, Science (General), Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：27 下载：28]
Combining Active Site and Allosteric Inhibitors to Study Protein Tyrosine Kinases

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[bivalent kinase inhibitors, synergy between allosteric and active site inhibitrs, Biological Chemistry, Pharmacy and Pharmacology, Chemistry, Science (General), Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：10 下载：13]
Designing Thermal Modulators for Portable GC x GC Systems.

颁布单位：[University of Michigan] | 颁布时间：2015 | 实施时间：2015 | 学科分类：[microscale thermal modulator, two dimensional gas chromatography, Thermal modulation model, MEMS, Electrical Engineering, Engineering (General), Mechanical Engineering, Chemistry, Physics, Science (General), Engineering, Health Sciences, Science, Mechanical Engineering]

预览 | 原文链接 [浏览：11 下载：1]
Peptide and Nonpeptide Approaches to Target Protein-protein Interactions for the Treatment of Cancer.

颁布单位：[University of Michigan] | 颁布时间：2015 | 实施时间：2015 | 学科分类：[Protein-Protein Interactions, RAP1, NF-κB, Stapled peptide, BET bromodomain, small-molecule inhibitor, cancer, Oncology and Hematology, Pharmacy and Pharmacology, Chemistry, Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：23 下载：15]
Examination of Aggregation Prone Proteins and their Higher Order Interactions by Ion Mobility-Mass Spectrometry.

颁布单位：[University of Michigan] | 颁布时间：2015 | 实施时间：2015 | 学科分类：[Protein Aggregration, Amyloid Beta, Ion Mobility Mass Spectrometry, Biological Chemistry, Chemistry, Health Sciences, Science, Chemistry]

预览 | 原文链接 [浏览：6 下载：9]