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Science

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Identification and Evaluation of Bacterial RNA Polymerase Inhibitors Using a Novel Plasmid-based Transcription Assay

颁布单位：[University of Michigan] | 颁布时间：2017 | 实施时间：2017 | 学科分类：[RNA polymerase, transcription, drug discovery, rifampin, high-throughput screen, tuberculosis, Biological Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：40 下载：6]
Development, Synthesis, and Characterization of G Protein-Coupled Receptor Kinase Inhibitors Using Structure Based Drug Design for the Advancement of Heart Failure Therapeutics

颁布单位：[University of Michigan] | 颁布时间：2017 | 实施时间：2017 | 学科分类：[Medicinal Chemistry, GRK Inhibitors, Heart Failure Therapeutics, G-protein couple receptor kinases, Structural Biology, Biological Chemistry, Pharmacy and Pharmacology, Chemistry, Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：17 下载：8]
Fluorescent Labeling, Co-Tracking, and Quantification of RNA In Cellulo.

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[Intracellular Single-Molecule Fluorescence Microscopy of RNA, RNA Induced Silencing Complex, microRNA, Fluorescent labeling of mRNA, Biological Chemistry, Science, Chemical Biology]

预览 | 原文链接 [浏览：30 下载：15]
Heat Shock Protein 70 (Hsp70) Acts as a Guardian Against Multiple Cell Death Pathways.

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[Chemical Probes Against Hsp70 Reveal Cytoprotective Activities, Biological Chemistry, Science, Chemical Biology]

预览 | 原文链接 [浏览：14 下载：0]
Structural and Functional Insights into the Type II Secretion System of Vibrio cholerae.

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[Microbiology, Zinc, Type II Secretion, Protein, Biological Chemistry, Microbiology and Immunology, Science (General), Health Sciences, Science, Microbiology and Immunology]

预览 | 原文链接 [浏览：37 下载：17]
Targeting the menin-MLL-LEDGF Interaction with Small Molecule Inhibitors.

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[Small molecule inhibitors, protein-protein interaction, Biological Chemistry, Science, Molecular & Cellular Pathology]

预览 | 原文链接 [浏览：23 下载：1]
Substrate Recognition by Protein-only Ribonuclease Ps

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[Ribonuclease P, RNase P, PRORP, Biological Chemistry, Science, Biological Chemistry]

预览 | 原文链接 [浏览：33 下载：25]
Immobilized Enzymes: Activity, Orientation, and Stability.

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[Immobilized enzymes, Nitroreductase, Self-assembling monolayers, Enzyme kinetics, Enzyme stability, Enzyme orientation, Biological Chemistry, Science, Chemical Biology]

预览 | 原文链接 [浏览：45 下载：34]
Mechanistic and Structural Insights into the Chemical Modulation of Amyloid Aggregation

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[Protein Aggregation, Amyloids, Alzheimer", s disease, Biological Chemistry, Chemistry, Science, Chemistry]

预览 | 原文链接 [浏览：30 下载：26]
Probing the Mechanisms of Aldehyde Decarbonylation Using Radical Clock Substrate Analogues.

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[Radical Clock, Aldehyde Decarbonylation, Biofuel, Biological Chemistry, Science, Biological Chemistry]

预览 | 原文链接 [浏览：41 下载：9]