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Medicinal Chemistry

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Substrate-Competitive Inhibitors of c-Src Kinase.

颁布单位：[University of Michigan] | 颁布时间：2014 | 实施时间：2014 | 学科分类：[medicinal chemistry, kinase, substrate-competitive inhibitor, substrate activity screening, Src, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：29 下载：36]
Synthetic and Biocatalytic Methods for the Chemoenzymatic Production of Novel Cryptophycin Anticancer Agents.

颁布单位：[University of Michigan] | 颁布时间：2013 | 实施时间：2013 | 学科分类：[Medicinal Chemistry, Cancer, Cryptophycin, Natural Products, Chemoenzymatic, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：19 下载：4]
Phage Display as a Tool for Probing Lipid A Biosynthesis.

颁布单位：[University of Michigan] | 颁布时间：2013 | 实施时间：2013 | 学科分类：[Lipid A, Phage Display, LpxA, LpxD, Escherichia Coli, Biological Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：48 下载：58]
Development of a Novel Class of Multifunctional Virulence-Attenuating Antibiotics.

颁布单位：[University of Michigan] | 颁布时间：2013 | 实施时间：2013 | 学科分类：[Antibiotics, Group a Streptococcus, Structure Activity Relationship, Macromolecular Target Identification, Biofilm Inhibition, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：42 下载：2]
Incorporation of Protein Flexibility in Structure-Based Drug Discovery of HIV-1 Protease and Bacterial Hsp70 Chaperone.

颁布单位：[University of Michigan] | 颁布时间：2013 | 实施时间：2013 | 学科分类：[Medicinal Chemistry, Computational Chemistry, Protein Dynamics, Drug Discovery, HIV Protease, Heat Shock Protein 70 Hsp70 Chaperone, Biological Chemistry, Pharmacy and Pharmacology, Chemistry, Science (General), Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：31 下载：12]
Molecular Recognition of Small Molecules by Rho-associated Kinase.

颁布单位：[University of Michigan] | 颁布时间：2013 | 实施时间：2013 | 学科分类：[Lead Optimization, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：9 下载：12]
The Mu and Delta Opioid Receptors:Mixed Efficacy Ligands and Receptor Trafficking.

颁布单位：[University of Michigan] | 颁布时间：2013 | 实施时间：2013 | 学科分类：[Interactions of Mu and Delta Opioid Receptors, Biological Chemistry, Pharmacy and Pharmacology, Science (General), Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：50 下载：1]
Structure Based Design of Peptidomimetic Inhibitors of the MLL1-WDR5 Interaction.

颁布单位：[University of Michigan] | 颁布时间：2012 | 实施时间：2012 | 学科分类：[MLL1 Inhibitor, WDR5 Inhibitor, MLL1-WDR5 Interaction Inhibitor, MLL1 Mimetic, HoxA9, Histone 3 Lysine 4 Methylation, Chemistry, Science (General), Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：25 下载：20]
Substrate Specificity of Metal-Dependent Lysine Deacetylases.

颁布单位：[University of Michigan] | 颁布时间：2012 | 实施时间：2012 | 学科分类：[KDAC8, KDAC11, Biological Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：15 下载：3]
Synthesis of Tritium Labeled Queuine, PreQ1 and Related Azide Probes TowardExamining the Prevalence of Queuine.

颁布单位：[University of Michigan] | 颁布时间：2012 | 实施时间：2012 | 学科分类：[Queuine, PreQ1, Synthesis of Pyrrolopyrimidine, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：34 下载：24]