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Medicinal Chemistry

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Synthetic and Biocatalytic Methods for the Chemoenzymatic Production of Novel Cryptophycin Anticancer Agents.

颁布单位：[University of Michigan] | 颁布时间：2013 | 实施时间：2013 | 学科分类：[Medicinal Chemistry, Cancer, Cryptophycin, Natural Products, Chemoenzymatic, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：23 下载：4]
Phage Display as a Tool for Probing Lipid A Biosynthesis.

颁布单位：[University of Michigan] | 颁布时间：2013 | 实施时间：2013 | 学科分类：[Lipid A, Phage Display, LpxA, LpxD, Escherichia Coli, Biological Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：50 下载：58]
Molecular Recognition of Small Molecules by Rho-associated Kinase.

颁布单位：[University of Michigan] | 颁布时间：2013 | 实施时间：2013 | 学科分类：[Lead Optimization, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：11 下载：12]
Development of a Novel Class of Multifunctional Virulence-Attenuating Antibiotics.

颁布单位：[University of Michigan] | 颁布时间：2013 | 实施时间：2013 | 学科分类：[Antibiotics, Group a Streptococcus, Structure Activity Relationship, Macromolecular Target Identification, Biofilm Inhibition, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：46 下载：2]
Synthesis of Tritium Labeled Queuine, PreQ1 and Related Azide Probes TowardExamining the Prevalence of Queuine.

颁布单位：[University of Michigan] | 颁布时间：2012 | 实施时间：2012 | 学科分类：[Queuine, PreQ1, Synthesis of Pyrrolopyrimidine, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：36 下载：24]
Towards Understanding and Overcoming the Antibiotic Resistance Conferred by Acetyltransferases.

颁布单位：[University of Michigan] | 颁布时间：2012 | 实施时间：2012 | 学科分类：[Antibacterial Resistance, Biological Chemistry, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：11 下载：4]
Understanding and Developing PikC as a Tool in Organic Synthesis. Part I: Total Synthesis of Methymycin and Neomethymycin Featuring a Catalytic Nickel Ynal Cyclization and a Biocatalytic PikC CH Oxidation. Part II: Regiodivergent Nickel Catalyzed Macrocyc

颁布单位：[University of Michigan] | 颁布时间：2012 | 实施时间：2012 | 学科分类：[Nickel Catalyzed Macrocyclization, Methymycin and NeomethymycinTotal Synthesis, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：16 下载：0]
Structure Based Design of Peptidomimetic Inhibitors of the MLL1-WDR5 Interaction.

颁布单位：[University of Michigan] | 颁布时间：2012 | 实施时间：2012 | 学科分类：[MLL1 Inhibitor, WDR5 Inhibitor, MLL1-WDR5 Interaction Inhibitor, MLL1 Mimetic, HoxA9, Histone 3 Lysine 4 Methylation, Chemistry, Science (General), Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：28 下载：20]
Substrate Specificity of Metal-Dependent Lysine Deacetylases.

颁布单位：[University of Michigan] | 颁布时间：2012 | 实施时间：2012 | 学科分类：[KDAC8, KDAC11, Biological Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：17 下载：3]
A Subcellular Compartmental Modeling Approach to Pulmonary Drug Development.

颁布单位：[University of Michigan] | 颁布时间：2011 | 实施时间：2011 | 学科分类：[Pharmacokinetics of Inhaled Drugs, 1Cell PK Model, Lung PBPK Model, Modeling and Simulations, Dissolution-Absorption Model, Biomedical Engineering, Complementary and Alternative Medicine, Pharmacy and Pharmacology, Chemistry, Science (General), Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：56 下载：3]