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Medicinal Chemistry

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Decoding the Bio-Assembly of Hapalindole-Type Alkaloids from Cyanobacteria for Drug Discovery

颁布单位：[University of Michigan] | 颁布时间：2017 | 实施时间：2017 | 学科分类：[biosynthetic pathway, hapalindole-type alkaloids, cyanobacteria, natural products, Cope rearrangement, drug discovery, Biological Chemistry, Chemistry, Genetics, Natural Resources and Environment, Science (General), Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：26 下载：2]
Structure Based Design of Peptidomimetic Inhibitors of the MLL1-WDR5 Interaction.

颁布单位：[University of Michigan] | 颁布时间：2012 | 实施时间：2012 | 学科分类：[MLL1 Inhibitor, WDR5 Inhibitor, MLL1-WDR5 Interaction Inhibitor, MLL1 Mimetic, HoxA9, Histone 3 Lysine 4 Methylation, Chemistry, Science (General), Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：25 下载：20]
Peptide and Nonpeptide Approaches to Target Protein-protein Interactions for the Treatment of Cancer.

颁布单位：[University of Michigan] | 颁布时间：2015 | 实施时间：2015 | 学科分类：[Protein-Protein Interactions, RAP1, NF-κB, Stapled peptide, BET bromodomain, small-molecule inhibitor, cancer, Oncology and Hematology, Pharmacy and Pharmacology, Chemistry, Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：23 下载：15]
Small Molecule Modulators of Transcription.

颁布单位：[University of Michigan] | 颁布时间：2010 | 实施时间：2010 | 学科分类：[Gene Transcription, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：22 下载：17]
Structure-Based Design, Synthesis and Evaluation of Novel and Selective Small-Molecule Inhibitors of the Anti-Apoptotic Protein Mcl-1.

颁布单位：[University of Michigan] | 颁布时间：2014 | 实施时间：2014 | 学科分类：[Anti-apoptotic Mcl-1, Medicinal Chemistry, Protein-protein Interaction Inhibitor, Cancer, Protein NMR Spectroscopy, Structure-activity Relationship, Biological Chemistry, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：21 下载：2]
Inhibiting the Actions of Essential Biomolecule Phosphopantetheine.

颁布单位：[University of Michigan] | 颁布时间：2015 | 实施时间：2015 | 学科分类：[Coenzyme A, Phosphopantothenoylcysteine synthetase, Saturation Mutagenesis, Lipid A, Acyltransferases, Biological Chemistry, Pharmacy and Pharmacology, Chemistry, Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：20 下载：2]
Synthetic and Biocatalytic Methods for the Chemoenzymatic Production of Novel Cryptophycin Anticancer Agents.

颁布单位：[University of Michigan] | 颁布时间：2013 | 实施时间：2013 | 学科分类：[Medicinal Chemistry, Cancer, Cryptophycin, Natural Products, Chemoenzymatic, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：19 下载：4]
Protein Flexibility in Structure-Based Drug Design.

颁布单位：[University of Michigan] | 颁布时间：2011 | 实施时间：2011 | 学科分类：[Protein Flexibility, Molecular Dynamics, Computational Chemistry, Mixed Solvent, HIV-1 Protease, Probe Mapping, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：16 下载：17]
Design, Synthesis, and Optimization of Opioid Receptor Peptidomimetics.

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[peptidomimetics, mu agonist/delta antagonist, opioid analgesics, synthetic medicinal chemistry, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：15 下载：14]
Development, Synthesis, and Characterization of G Protein-Coupled Receptor Kinase Inhibitors Using Structure Based Drug Design for the Advancement of Heart Failure Therapeutics

颁布单位：[University of Michigan] | 颁布时间：2017 | 实施时间：2017 | 学科分类：[Medicinal Chemistry, GRK Inhibitors, Heart Failure Therapeutics, G-protein couple receptor kinases, Structural Biology, Biological Chemistry, Pharmacy and Pharmacology, Chemistry, Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：15 下载：8]