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Medicinal Chemistry

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Drug-Oriented Synthesis of Cardiotonic Steroids

颁布单位：[University of Michigan] | 颁布时间：2017 | 实施时间：2017 | 学科分类：[cardiotonic steroids, synthetic organic chemistry, medicinal chemistry, total synthesis, cardenolide, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：26 下载：3]
Decoding the Bio-Assembly of Hapalindole-Type Alkaloids from Cyanobacteria for Drug Discovery

颁布单位：[University of Michigan] | 颁布时间：2017 | 实施时间：2017 | 学科分类：[biosynthetic pathway, hapalindole-type alkaloids, cyanobacteria, natural products, Cope rearrangement, drug discovery, Biological Chemistry, Chemistry, Genetics, Natural Resources and Environment, Science (General), Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：26 下载：2]
Modulating the Global Conformations of c-Src Kinase

颁布单位：[University of Michigan] | 颁布时间：2017 | 实施时间：2017 | 学科分类：[Kinase, c-Src, Conformation, Medicinal Chemistry, Chemical Biology, Biological Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：35 下载：86]
Development, Synthesis, and Characterization of G Protein-Coupled Receptor Kinase Inhibitors Using Structure Based Drug Design for the Advancement of Heart Failure Therapeutics

颁布单位：[University of Michigan] | 颁布时间：2017 | 实施时间：2017 | 学科分类：[Medicinal Chemistry, GRK Inhibitors, Heart Failure Therapeutics, G-protein couple receptor kinases, Structural Biology, Biological Chemistry, Pharmacy and Pharmacology, Chemistry, Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：15 下载：8]
Synthesis and Evaluation of Mixed Efficacy Mu Opioid Receptor (MOR), Delta Opioid Receptor (DOR) Peptidomimetic Ligands.

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[Opioid, Peptidomimetic, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：35 下载：21]
Chemical Modulators of Heat Shock Protein 70 (Hsp70) Validate this Molecular Chaperone as a Target for Tauopathy

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[Hsp70, Biological Chemistry, Chemistry, Molecular, Cellular and Developmental Biology, Science (General), Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：11 下载：22]
Design, Synthesis, and Optimization of Opioid Receptor Peptidomimetics.

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[peptidomimetics, mu agonist/delta antagonist, opioid analgesics, synthetic medicinal chemistry, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：15 下载：14]
An Antibiotic Discovery Campaign Targeting VirF, the Main Transcriptional Regulator of Virulence in Shigella flexneri

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[Antibiotic Discovery Campaign, Shigella, Anti-virulence, VirF, Biological Chemistry, Microbiology and Immunology, Pharmacy and Pharmacology, Chemistry, Science (General), Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：27 下载：28]
Combining Active Site and Allosteric Inhibitors to Study Protein Tyrosine Kinases

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[bivalent kinase inhibitors, synergy between allosteric and active site inhibitrs, Biological Chemistry, Pharmacy and Pharmacology, Chemistry, Science (General), Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：10 下载：13]
Development of Novel Anticancer Therapeutics: Total Synthesis of Lactimidomycin and its Analogs and Synthetic Strategies Towards Diterpene Natural Products.

颁布单位：[University of Michigan] | 颁布时间：2015 | 实施时间：2015 | 学科分类：[Organic Chemistry, Medicinal Chemistry, Lactimidomycin, Total Synthesis of Natural Products, Diterpene-Based Small Molecules, Anticancer Therapeutics, Chemistry, Science (General), Science, Chemistry]

预览 | 原文链接 [浏览：104 下载：61]