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Medicinal Chemistry

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An Antibiotic Discovery Campaign Targeting VirF, the Main Transcriptional Regulator of Virulence in Shigella flexneri

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[Antibiotic Discovery Campaign, Shigella, Anti-virulence, VirF, Biological Chemistry, Microbiology and Immunology, Pharmacy and Pharmacology, Chemistry, Science (General), Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：27 下载：28]
Combining Active Site and Allosteric Inhibitors to Study Protein Tyrosine Kinases

颁布单位：[University of Michigan] | 颁布时间：2016 | 实施时间：2016 | 学科分类：[bivalent kinase inhibitors, synergy between allosteric and active site inhibitrs, Biological Chemistry, Pharmacy and Pharmacology, Chemistry, Science (General), Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：10 下载：13]
Development of Novel Anticancer Therapeutics: Total Synthesis of Lactimidomycin and its Analogs and Synthetic Strategies Towards Diterpene Natural Products.

颁布单位：[University of Michigan] | 颁布时间：2015 | 实施时间：2015 | 学科分类：[Organic Chemistry, Medicinal Chemistry, Lactimidomycin, Total Synthesis of Natural Products, Diterpene-Based Small Molecules, Anticancer Therapeutics, Chemistry, Science (General), Science, Chemistry]

预览 | 原文链接 [浏览：104 下载：61]
Peptide and Nonpeptide Approaches to Target Protein-protein Interactions for the Treatment of Cancer.

颁布单位：[University of Michigan] | 颁布时间：2015 | 实施时间：2015 | 学科分类：[Protein-Protein Interactions, RAP1, NF-κB, Stapled peptide, BET bromodomain, small-molecule inhibitor, cancer, Oncology and Hematology, Pharmacy and Pharmacology, Chemistry, Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：23 下载：15]
Type I Polyketide Synthases:Methodology, Biocatalysis, and Evaluation of Substrate Promiscuity.

颁布单位：[University of Michigan] | 颁布时间：2015 | 实施时间：2015 | 学科分类：[polyketide synthases, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：43 下载：16]
Incorporating Hotspot Mapping and Allostery in Structure Based Drug Design.

颁布单位：[University of Michigan] | 颁布时间：2015 | 实施时间：2015 | 学科分类：[Computational Chemistry, Structure Based Drug Design, Molecular Dynamics Simulations, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：29 下载：15]
Inhibiting the Actions of Essential Biomolecule Phosphopantetheine.

颁布单位：[University of Michigan] | 颁布时间：2015 | 实施时间：2015 | 学科分类：[Coenzyme A, Phosphopantothenoylcysteine synthetase, Saturation Mutagenesis, Lipid A, Acyltransferases, Biological Chemistry, Pharmacy and Pharmacology, Chemistry, Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：20 下载：2]
Structure-Based Design, Synthesis and Evaluation of Novel and Selective Small-Molecule Inhibitors of the Anti-Apoptotic Protein Mcl-1.

颁布单位：[University of Michigan] | 颁布时间：2014 | 实施时间：2014 | 学科分类：[Anti-apoptotic Mcl-1, Medicinal Chemistry, Protein-protein Interaction Inhibitor, Cancer, Protein NMR Spectroscopy, Structure-activity Relationship, Biological Chemistry, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：19 下载：2]
Synthesis and Biochemical Evaluation of Multifunctional Acetylcholinesterase Inhibitor Hybrids for Treatment of Alzheimer's Disease.

颁布单位：[University of Michigan] | 颁布时间：2014 | 实施时间：2014 | 学科分类：[Alzheimer", s Disease, Acetylcholinesterase, Amyloid-beta, Tacrine, Mefenamic Acid, Multifunctional Molecules, Biological Chemistry, Neurosciences, Pharmacy and Pharmacology, Chemistry, Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：84 下载：20]
Developing a Bacterial P450 as a General and Regioselective Catalyst for C-H Bond Oxidation.

颁布单位：[University of Michigan] | 颁布时间：2014 | 实施时间：2014 | 学科分类：[C-H Functionalization, Bio-catalysis, Organic Synthesis, Enzymes, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：67 下载：31]