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Biological Chemistry

2014

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Structure-Based Design, Synthesis and Evaluation of Novel and Selective Small-Molecule Inhibitors of the Anti-Apoptotic Protein Mcl-1.

颁布单位：[University of Michigan] | 颁布时间：2014 | 实施时间：2014 | 学科分类：[Anti-apoptotic Mcl-1, Medicinal Chemistry, Protein-protein Interaction Inhibitor, Cancer, Protein NMR Spectroscopy, Structure-activity Relationship, Biological Chemistry, Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：24 下载：28]
Structural Analysis of Mechanism and Regulation of Glutamine Amidotransferases.

颁布单位：[University of Michigan] | 颁布时间：2014 | 实施时间：2014 | 学科分类：[glutamine amidotransferases, X-ray crystallography, Biological Chemistry, Science, Biological Chemistry]

预览 | 原文链接 [浏览：21 下载：11]
Mechanism of Nucleotide Flipping by Human Alkyladenine DNA Glycosylase.

颁布单位：[University of Michigan] | 颁布时间：2014 | 实施时间：2014 | 学科分类：[Kinetic mechanism of a DNA repair protein, Biological Chemistry, Science, Biological Chemistry]

预览 | 原文链接 [浏览：5 下载：0]
Heterogeneous Folding and Function of Small RNA Motifs:The Hairpin Ribozyme and a Translational Riboswitch.

颁布单位：[University of Michigan] | 颁布时间：2014 | 实施时间：2014 | 学科分类：[RNA Structure, Heterogeneity, Biological Chemistry, Science, Cellular and Molecular Biology]

预览 | 原文链接 [浏览：17 下载：12]
Synthesis and Biochemical Evaluation of Multifunctional Acetylcholinesterase Inhibitor Hybrids for Treatment of Alzheimer's Disease.

颁布单位：[University of Michigan] | 颁布时间：2014 | 实施时间：2014 | 学科分类：[Alzheimer", s Disease, Acetylcholinesterase, Amyloid-beta, Tacrine, Mefenamic Acid, Multifunctional Molecules, Biological Chemistry, Neurosciences, Pharmacy and Pharmacology, Chemistry, Health Sciences, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：92 下载：20]
Structures, Dynamics, and Ribozymes:An Investigation of RNA Structural Dynamics with the Hepatitis Delta Virus and Hairpin Ribozymes.

颁布单位：[University of Michigan] | 颁布时间：2014 | 实施时间：2014 | 学科分类：[Structural Dynamics of HDV and Hairpin Ribozymes, MD Simulations, Single Molecule FRET, Intracellular Interactions With RNA, Macromolecular Crowding, Biological Chemistry, Chemistry, Science (General), Science, Chemical Biology]

预览 | 原文链接 [浏览：24 下载：16]
Protein-Protein Interactions in the Mammalian Heme Degradation Pathway: Heme Oxygenase-2, Cytochrome P450 Reductase and Biliverdin Reductase.

颁布单位：[University of Michigan] | 颁布时间：2014 | 实施时间：2014 | 学科分类：[Protein-protein interactions involving heme oxygenase, cytochrome P450 reductase and biliverdin reductase, electron transfer complex, Biological Chemistry, Molecular, Cellular and Developmental Biology, Science (General), Science, Cellular and Molecular Biology]

预览 | 原文链接 [浏览：15 下载：0]
The 70-kDa Heat Shock Protein (Hsp70) Chaperone System: Linking ATP Turnover and Complex Formation To Protein Homeostasis.

颁布单位：[University of Michigan] | 颁布时间：2014 | 实施时间：2014 | 学科分类：[Chemical Biology, Microtubule Associated Protein Tau (MAPT), Molecular Chaperones, Hsp70, Protein Complexes, Biological Chemistry, Pathology, Science (General), Health Sciences, Science, Chemical Biology]

预览 | 原文链接 [浏览：32 下载：15]
Single-Molecule Microscopy Studies of Interactions between Alzheimer's Amyloid-(1-40) and Amyloid-(1-42) on the Membrane.

颁布单位：[University of Michigan] | 颁布时间：2014 | 实施时间：2014 | 学科分类：[Alzheimer", Amyloid-beta, Single Molecule Microscopy, In Vivo Imaging, Protein Membrane Interactions Aggregation, Biological Chemistry, Physics, Science, Biophysics]

预览 | 原文链接 [浏览：21 下载：29]
Development of Small Molecule Replication Inhibitors Against Western Equine Encephalitis Virus.

颁布单位：[University of Michigan] | 颁布时间：2014 | 实施时间：2014 | 学科分类：[alphavirus, antivirals, Biological Chemistry, Science, Medicinal Chemistry]

预览 | 原文链接 [浏览：41 下载：16]