Genomic Identification and Analysis of Shared Cis-regulator Elements in a Developmentally Critical homeobox Cluster

[摘要] The goals of this project were to isolate, characterize, and sequence the Dlx3/Dlx7 bigene cluster from twelve different species of mammals. The Dlx3 and Dlx7 genes are known to encode homeobox transcription factors involved in patterning of structures in the vertebrate jaw as well as vertebrate limbs. Genomic sequences from the respective taxa will subsequently be compared in order to identify conserved non-coding sequences that are potential cis-regulatory elements. Based on the comparisons they will fashion transgenic mouse experiments to functionally test the strength of the potential cis-regulatory elements. A goal of the project is to attempt to identify those elements that may function in coordinately regulating both Dlx3 and Dlx7 functions.

[发布日期] 2003-04-01 [发布机构] Benaroya Research Institute of Virginia Mason

[关键词] Genes;Transcription Factors;59 Basic Biological Sciences;Vertebrates;Mammals