Linking Molecular Events to Cellular Responses at Low Dose Exposures

[摘要] The studies proposed in this project are to define thresholds in cell signaling pathways that are required for cellular transformation and may be targeted by low-dose radiation. Defining thresholds in transformation-related signal transduction pathways that are sensitive to low-dose radiation would be an important advancement in risk assessment and could be used to demonstrate nonlinear relationships between low-dose radiation and cancer.

[发布日期] 2000-06-01 [发布机构] Pacific Northwest National Laboratory (U.S.)

[关键词] 63 Radiation, Thermal, And Other Environmental Pollutant Effects On Living Organisms And Biological Materials;Neoplasms;54 Environmental Sciences;Radiations;Risk Assessment