Final Report on Grant DE-FG03-02ER63470

[摘要] The goal of this project is to provide critical information to characterize the qualitative and quantitative similarities and difference in repair characteristics between clustered damage sites formed by ionizing radiation and singly damaged sites produced by endogenous processes. The premise is that base pairing and base stacking interactions are qualitatively and quantitatively different for singly and multiply damaged DNA sites. State-of-the-art computational chemistry model were used to characterize the structure, energetics, and spectroscopy of singly and multiply damaged (clustered) DNA sites.

[发布日期] 2006-11-20 [发布机构] Washington State University

[关键词] Repair;Dna;Dna Damage And Repair;Free Energy Of Duplex Dna Destabilization;Ionizing Radiations