Transporting silence: Design of carriers for siRNA to angiogenic endothelium

[摘要] The recently developed siRNA oligonucleotides are an attractive alternative to antisense as a therapeutic modality because of their robust, gene selective silencing of drug target protein expression. To achieve therapeutic success, however, several hurdles must be overcome including rapid clearance, nuclease degradation, and inefficient intracellular localization. In this presentation, we discuss design strategies for development of self-assembling nanoscale carriers for neovasculature targeted delivery of siRNA inhibiting tumor or ocular angiogenesis. (c) 2005 Elsevier B.V. All rights reserved.

[发布日期] 2005-12-05

[效力级别]  Proceedings Paper

[关键词] RNA interference;siRNA;drug targeting;angiogenesis