Simple diagnosis of graft-versus-host disease

[摘要] Background: Among patients undergoing allogeneic bone marrow transplantation. we previously detected an increase of CD8+S6F1+ and CD8+CD57- cells with the onset of acute graft-versus-host disease. Objective: This study was an attempt to develop a simple laboratory test for graft-versus-host disease. Methods: we analyzed the percentage of the two lymphocyte subsets in the peripheral blood mononuclear cells of healthy volunteers, patients with posttransfusion graft-versus-host disease, and recipients of allogeneic bone marrow transplants. Results: Two patients with posttransfusion graft-versus-host disease showed a high percentage of both subsets. When graft-versus-host disease pattern was defined as 45% or more CD8+S6F1+ cells and 35% or more CD8+CD57- cells, was found in none of 17 recipients without acute graft-versus-host disease, 9 of 16 recipients with grade I disease, 8 of 9 recipients with grade II or worse disease had this tern. Conclusions: Our test may he useful for the laboratory diagnosis of acute graft-versus-host disease.

[发布日期] 1997-12-01

[效力级别]  Proceedings Paper

[关键词] graft-versus-host disease;lymphocyte subset;bone marrow transplantation;blood transfusion