Antibody-directed therapy: Past, present, and future

[摘要] Antibody-based therapy, which is the administration of polyclonal, hyperimmune, or monoclonal antibodies, has emerged as an important therapeutic approach in a wide variety of diseases. Polyclonal intravenous immunoglobulin became available in the early 1980s and supplanted intramuscular IgG in the treatment of antibody-deficiency diseases. During the last 2 decades, intravenous immunoglobulin has shown potent immunomodulatory and anti-inflammatory effects in many diseases. Whether these effects are mediated through specific antibody or Fc-receptor interactions is unclear. This review examines some of the current and future prospects for antibody-based therapy.

[发布日期] 2001-10-01

[效力级别]  Proceedings Paper

[关键词] anti-inflammatory;autoimmunity;monoclonal antibody;polyclonal antibody;hyperimmune Igs;immunomodulation