MYOCARDIAL SPECIFIC CREATINE-PHOSPHOKINASE ISOENZYME ELEVATION IN CHILDREN WITH ASTHMA TREATED WITH INTRAVENOUS ISOPROTERENOL

[摘要] We retrospectively reviewed admissions that required intravenous (IV) isoproterenol in an intensive care unit setting for management of severe childhood status asthmatics. Elevation of the cardiac-specific serum creatine phosphokinase MB (CPK-MB) isoenzyme was noted in 15 of 19 admissions. The mean peak elevation of serum CPK in those 15 admissions was 204 IU/L with a mean peak MB band of 6.05%. Nine of the 15 admissions with elevated CPK-MB level had follow-up levels measured after IV isoproterenol had been stopped. In all nine cases, the follow-up serum CPK-MB level was 0%. In six of those nine cases, follow-up serum with undetectable CPK-MB level was obtained while the patients continued to receive IV aminophylline and corticosteroids, and inhaled but not intravenous .beta.-adrenergic agonist medications. These observations suggest that elevated serum BPK-MB levels that may be indicative of myocardial injury are associated with IV isoproterenol therapy of severe childhood asthma. Therefore, we recommended caution along with serial monitoring of serum CPK-MB levels when IV isoproterenol is administered in the therapy of childhood asthma.

[发布日期] 1986-10-01