Role of costimulatory pathways in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis

[摘要] Multiple sclerosis is an immune-mediated disorder of the central nervous system. T lymphocytes are thought to play a central role in the initiation and potentially in the propagation of this disease. Two signals are required for T-cell activation. The first signal consists of the interaction of the T-cell receptor with antigen presented by the MHC molecule on antigen-presenting cells. The second signal requires engagement of costimulatory receptors on T cells with their ligands on antigen-presenting cells. Several costimulatory pathways have been shown to play an important role in T-lymphocyte activation. Here we will review the current literature on the contribution of the B7-1/2-CD28/CTLA-4, inducible costimulatory molecule-B7h, programmed death pathway 1-programmed death pathway ligand 1/ligaDd 2, CD40-CD154, OX40-OX40 ligand, and CD137-CD137 ligand pathways to the pathogenesis of multiple sclerosis and their potential roles as therapeutic targets.

[发布日期] 2003-11-01

[关键词] B7-1;B7-2;CD28;CD40;CD137 (4-IBB);CD154;(CD40 ligand);costimulation;CTLA-4 (CD152);CTLA41g;experimental autoimmune encephalomyelitis;inducible costimulatory molecule;multiple sclerosis;programmed death pathway 1;programmed death pathway ligand 1;programmed death pathway ligand 2;OX40 (CD134);OX40 ligand (CD134L)