LYMPHOCYTE SUBPOPULATIONS OF ATOPIC CHILDREN AND EFFECT OF THERAPY UPON THEM

[摘要] Recent reports note decreased T [thymus-derived] cell function in association with certain atopic conditions in man. This study was performed to determine whether numbers of circulating T cells are decreased in atopic children and adolescents in comparison with nonatopic age-matched control subjects. The subjects were not selected on the basis of a particular atopic diagnosis, but relatively more had allergic rhinitis and/or asthma (52) than had atopic eczema (7). Numbers of circulating T cells were not significantly different in allergic children ages 2-10 yr than in control subjects. Atopic children and adolescents over age 10 yr had significantly fewer T cells in relative percentages (P < 0.05), but when absolute numbers were considered significance was lost. Atopic children aged 2-10 yr had significantly more B [bone marrow-derived] cells in relative percentages and absolute numbers than did control subjects (P < 0.02 and P < 0.05, respectively). When those subjects treated with corticosteroids were separated from the total atopic group, there were no significant differences between the atopic and control subjects. Corticosteroids, bronchodilators, antihistamines and immunotherapy produced no consistent effect on lymphocyte subpopulations.