AIRWAY RESPONSE TO INHALED HISTAMINE IN ASYMPTOMATIC LONG-TERM MARIHUANA SMOKERS

[摘要] Bronchial challenge with histamine was used to assess bronchial reactivity in asymptomatic individuals who were long-term social smokers of marihuana. Their reactivity was compared to that of nonsmokers and asthmatics. Spirometry results were normal in the marihuana users. There was no significant difference in bronchial reactivity between marihuana smokers and nonsmoking controls, whereas the asthmatics demonstrated the expected hyperreactivity. The customary social use of marihuana may not produce abnormalities in airway function detectable by spirometry or bronchoprovocation.