THE EFFECT OF SINGLE AND MULTIPLE DOSE THERAPY WITH AZELASTINE ON THE IMMEDIATE ASTHMATIC RESPONSE TO ALLERGEN PROVOCATION TESTING

[摘要] The effect of 2.2 or 4.4 mg of azelastine administered orally on immediate allergen-induced airflow obstruction was studied in 20 young patients with asthma. Provocation testing was performed after a single oral dose of azelastine or placebo and repeated after 3 weeks of twice daily therapy with azelastine or placebo. After multiple dose therapy with 4.4 mg of azelastine for 21 days, significantly more allergen was required to produce a 35% fall in specific airways conductance than after placebo therapy (p < 0.008). Apart from a bitter, metallic taste in the mouth reported by 41.2% of the patients while they were receiving azelastine, no other unwanted effects were encountered.

[发布日期] 1986-08-01