BRONCHOSPASM CAUSED BY INTRAVENOUS HYDROCORTISONE SODIUM SUCCINATE (SOLU-CORTEF) IN ASPIRIN-SENSITIVE ASTHMATICS

[摘要] Patients (11) with intrinsic asthma and aspirin sensitivity were challenged with i.v. hydrocortisone sodium succinate (Solu-Cortef). Three patients showed definite evidence of bronchospasm, which was easily reversed by s.c. administration of epinephrine. This reaction was not caused by other constituents of the preparation but was caused by Solu-Cortef alone. No atopy was demonstrated in the group as a whole, and the reaction observed was probably nonallergic in nature. The replacement of i.v. hydrocortisone sodium succinate with dexamethasone in the treatment of such a population is suggested.