Maternal sex hormones in early pregnancy and asthma among offspring: A case-control study

[摘要] Background: Sex hormones may be associated with the risk of onset of asthma. Objective: To study the association between maternal sex hormone concentrations during early pregnancy and the risk of asthma among offspring. Methods: A case-control study of 129 asthmatic children and 125 control children 5 to 6 years of age. Maternal sera in early pregnancy were obtained from the Finnish Maternal Cohort serum bank. Results: The means of serum progesterone and estradiol and free estradiol in mothers of asthmatic and control children were 81.0 and 82.8 nmol/L (P = .60), 7.87 nmol/L and 7.65 nmol/L (P = .99), and 149.5 pmoI/L and 148.0 pmol/L (P = .95), respectively. There were also no differences in the mean concentrations of maternal sex hormones according to the presence of allergic rhinitis or atopic eczema among the children. Conclusions: The current results do not support an association between maternal sex hormone concentrations during early pregnancy and onset of allergic disease in early childhood.

[发布日期] 2003-12-01

[关键词] asthma;atopy;allergic disorders;childhood;sex hormones;pregnancy