REFRACTORY PERIOD TO ASPIRIN IN A PATIENT WITH ASPIRIN-INDUCED ASTHMA

[摘要] Oral aspirin challenge was used to detect unrecognized aspirin intolerance in a select group of 50 asthmatic patients who denied aspirin intolerance. A double-blind protocol was used to further study those patients who reacted to initial graded aspirin challenge. In 1 patient the use of a double-blind protocol led to the serendipitous discovery of a 72-h refractory period to the adverse effects of aspirin, after initial ingestion of aspirin resulted in respiratory and systemic symptoms.