Timing of surgery for aneurysmal subarachnoid hemorrhage: A systematic review and meta-analysis

[摘要] Introduction: The timing of surgery for aneurysmal subarachnoid hemorrhage influences the outcome, but the optimal timing remains controversial. We conducted a systematic review to clarify whether early surgery was better than late surgery for improving outcome. Materials and methods: We systematically searched several databases to screen eligible studies. After synthesizing data, an overall effect was shown using a risk ratio (RR) and 95% confidence interval (CI). Subgroup analyses were stratified by multiple variables to control the confounding factors. Sensitivity analyses were applied to check the robustness of the results. Publication bias was measured with Egger's and Begg's tests. Results: A total of 14 studies were included in the analysis. Compared with late surgery, early surgery significantly decreased the incidence of poor outcome, regardless of whether patients were in good condition (RR, 0.65 [95% CI, 0.50 0.84]; p = 0.001) or in poor condition on admission (RR, 0.71 [95% CI, 0.61 0.83]; p < 0.0001). Moreover, when patients were in good condition on admission, early surgery also effectively reduced the death rate (RR, 0.61 [95% CI, 0.46 0.82]; p = 0.001). Additionally, early surgery reduced the death rate compared with late surgery in patients older than 50 years (RR, 0.49 [95% CI, 0.27 0.89]; p < 0.002). Conclusions: Early surgery was superior to late surgery in reducing a poor outcome and death rate when patients were in good condition on admission, and decreased the incidence of poor outcome when patients were in poor condition on admission. Age was a potential confounding factor, influencing the effect of early surgery. Further study is required on this issue.

[发布日期] 2017-12-01

[关键词] Timing;Surgery;Aneurysm;Subarachnoid hemorrhage;Meta-analysis