Primary biliary cholangitis: A tale of epigenetically-induced secretory failure?

[摘要] Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease associated with auto-immunerelated destruction of small to medium size intrahepatic bile ducts. The aetiology of PBC is unknown and its pathogenesis remains obscure. Both genetic variants and environmental factors have been linked to increased PBC susceptibility, with other alterations known to cooperate in disease pathobiology. Increasing evidence indicates the presence of epigenetic abnormalities in PBC, particularly alterations of cholangiocellular microRNAs (miRNAs or miRs). This review highlights and discusses the most relevant epigenetic alterations found in patients with PBC, focusing on the role of miR-506 in the promotion of cholestasis and immune activation. (C) 2018 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

[发布日期] 2018-12-01

[关键词] PBC;Cholangiocytes;Biliary bicarbonate;AE2;miR-506