PENETRATION OF ANIONIC SURFACTANTS (SURFACE ACTIVE AGENTS) INTO SKIN .1. PENETRATION OF SODIUM LAURATE AND SODIUM DODECYL SULFATE INTO EXCISED HUMAN SKIN

[摘要] From weak, unbuffered, moldly alkaline aqueous solution, sodium laurate seems to be able to penetrate into the epidermis and dermis of excised human skin. From similar solutions sodium dodecyl sulfate, on the other hand, appears to penetrate only in very small quantities below the barrier of normal undamaged skin and for the most part to be retained in the stratum corneum. When in quite alkaline, buffered solutions (pH>10.5) both of these surfactants penetrate into the dermis. At this alkalinity the natural barrier is damaged.