GROUP SPECIFICITY OF EPIDERMAL ALLERGY TO PROCAINE IN MAN

[摘要] The influence of chemical configuration of [rho]-aminobenzoic acid esters upon the allergy against procaine was studied in eczematous contact-type reactions. The length of the side chain was irrelevant and also substitutions by alkyl groups of H atoms in the side chain or of one H atom in the aromatic amino group did not abolish the antigenic effectiveness. Benzoic acid esters with a tertiary amine in the side chain, but without an aromatic amino group, or with an amino group in meta- or ortho-position, were ineffective. The group specificity in epidermal allergy follows a pattern similar to that of serol. reactions.