COMPARATIVE STUDY ON THE EFFECT OF ANTICHOLINERGIC COMPOUNDS ON SWEATING

[摘要] 15 anticholinergic drugs given orally to man in clinical dosages proved to have no effect on pilocarpine-induced local sweating 2 hrs. after admn. High oral doses of atropine sulfate (3 mg.) significantly reduced pilocarpine sweating response during the period of from 30 to 60 min. after admn. Following topical admn. by iontophoresis, scopolamine HBr, atropine methyl nitrate, and atropine sulfate proved to be the most effective of 11 anticholinergic drugs in preventing local sweating in response to thermal stimulation. A single topical appln. of concd, aqueous solns. of scopolamine HBr (1-hyoscine HBr) induced local anhidrosis persisting for weeks after appln.