THE DISTRIBUTION OF RADIOACTIVE IODINE (I-131) IN EXPERIMENTAL COCCIDIOIDOMYCOSIS AND SPOROTRICHOSIS

[摘要] The uptake of I131 by the thyroid gland of mice infected with coccidioidomycosis and sporotrichosis was found to be significantly less in 24 and 48 hours than a similar group of control animals. The uptake of I131 at 12, 24, and 48 hours by the granulomatous tissues of mice with coccidioidomycosis was found to be significantly greater than by comparative control tissue. The uptake of I131 at 48 hours by the granulomatous tissues of mice with sporotrichosis was found to be significantly greater than comparative control tissue. This was not true at 12 and 24 hours. There was a marked alteration in the deposition of I131 in the livers of the animals with both coccidioidomycosis and sporotrichosis when compared to the livers of the control mice. Iodine was distributed evenly to the omentums, granulomatous tissues and the livers of the infected and control mice in both coccidioidomycosis and sporotrichosis when I131 was given daily over a 4-day period con- comitantly with large doses of I127.