EFFECTS PRODUCED ON THE PILOSEBACEOUS SYSTEM AND THE ADRENALS OF THE RABBIT BY INUNCTION OF SEX HORMONES

[摘要] Studies reported were concerned with the local and systemic effects of percutaneously applied sex hormones. Estrogens caused a reduction in size of sebaceous glands and stimulation of the hair papillae with an increase in rate of growth of the hair. With percutaneously applied testosterone there was a noted hyperplasia of the sebaceous glands and reduced activity of the pilar papillae, and decrease in the rate of growth of hair. After the application of testosterone for a certain length of time a reversible effect can be obtained with the use of estrogens and vice versa. Obvious changes occur in the cortex of adrenal glands. These may be observed for as long as 4 months after cessation of the hormones, but to a lesser degree than in the first month after continuous application. Similar changes, although to a lesser degree, also occur after the application of androgenic hormones.