A STUDY OF THE LOCAL TISSUE REACTIONS IN MAN TO CORTISONE AND COMPOUND-F .6. HISTOPATHOLOGICAL STUDIES OF THE LOCAL EFFECT OF COMPOUND-F IN NORMAL AND PATHOLOGIC SKIN OF MAN

[摘要] The local injn. of suspensions of Compound F acetate into human skin produces hematoxylinophilic masses persistent over a considerable period of time. Preliminary histochemical studies suggest that these are ground substance changes. The local injn. of free alcohol of Compound F, plate crystal type, does not produce similar reactions. Free alcohol of the rod crystal type produces less pronounced reactions. Biopsies of a variety of inflammatory conditions of the skin after local injn. of compound F acetate has revealed definite inhibition of inflammation in the eczematous, toxic (not too severe), tuberculin, psoriatic, sarcoidal, neuroder-matitic keloidal, lymphomatous and leukemic skin reactions and also in some miscellaneous disorders. Biopsies of the urticarial reaction and the local histamine wheal haverevealed no significant changes. Detailed histochemical studies are needed further to attempt to follow the local mechanisms of action of Compound F in the skin. It is suggested that a tissue as easily available as the skin be used in man to study some local mechanisms concerned in investigative studies in steroid biology in man.