TOPICAL HYPOSENSITIZATION OF ALLERGIC CONTACT SENSITIVITY IN THE GUINEA PIG

[摘要] Specific depression of allergic contact sensitivity can be produced in the previously sensitized guinea pig by daily topical application of small amounts of the antigen over a 2 week period. This is described with 2 antigens, dinitrochlorobenzene [DNCB] and Taractan, and is reported with a third P-nitrosodimethyl-aniline (NDMA). Such hyposensitization is more readily accomplished with some sensitizers (e.g., Taractan, NDMA) than with others (e.g., DNCB). During the early stages of hyposensitization, sensitivity to the compound being applied is depressed on untreated areas of skin, while inflammation occurs at the site of daily application. In the case of Taractan, inflammation at the site of application may be transient or mild. After daily application of the antigen was stopped, specific depression of sensitivity persisted for at least 5 weeks. Sensitivity could not be restored to hyposensitized animals by sensitization procedures which are usually quite effective. Hyposensitization procedures which effectively depress sensitivity in the sensitized animal do not prevent or delay appearance of sensitivity following initial exposure to the antigen.