LABORATORY STUDIES ON ENDOMYCIN - WITH SPECIAL REFERENCE TO ITS ANTIFUNGAL EFFECT AGAINST CANDIDA ALBICANS

[摘要] Endomycin exhibits an antifungal effect in vitro against C. albicans. The sensitivity of freshly isolated individual strains varies over a wide range of concentrations. Similar findings were noted in the case of C. tropicalis. Endomycin exerts a greater antifungal effect when the pH of the suspending medium is more alkaline. Strains of C. albicans were developed in vitro which became more resistant to endomycin. The occurrence of such resistance may reduce the anticipated clinical usefulness of the drug. Endomycin retains its potency in aqueous solution at room temperature over a prolonged period. Endomycin exhibits an inhibitory effect in vitro against various spp. of fungi causing superficial or deep mycoses.