EPIDERMAL WATER-BARRIER FORMATION AFTER STRIPPING OF NORMAL SKIN

[摘要] The average value of the insensible perspiration of any 0. 2 cm2 skin of the volar aspect of the forearm of several individuals is the same the values vary from day to day. Since these daily variations are not concurrent, and since there are also regional variations of the insensible perspiration, there is a pattern of different values of the water vapor loss at various sites of the forearm. Furthermore, this pattern varies daily. Stripping of the skin with sellotape causes damage of the skin barrier and resultant water vapor loss. The rate of regeneration is fairly constant except for seasonal variation (faster in the spring than in the autumn). Occasionally the regeneration of the final skin barrier proceeds as fast as the formation of the temporary barrier of parakeratotic cells. The progress of the regeneration as measured by the water vapor loss can be expressed mathematically: the regeneration of the barriers is characterized by its half regeneration time.