EFFECT OF PREDNISONE ON SEBACEOUS GLAND SECRETION

[摘要] The effect of adreno-cortical-suppressive doses of prednisone on sebum production was studied in normal males, normal females, and castrated males. No suppression of sebaceous gland secretion occurred in normal intact males. Female subjects demonstrated a variable but significant reduction (19%) in sebum output. Castrated males showed the highest degree of sebum suppression (40%). The failure to observe sebaceous gland inhibition in normal males is probably due to the overriding effect of stimulation by testicular androgen. A significant reduction in sebum secretion of normal females suggests a physiologic role of adrenal androgens in women for the stimulation of the androgen-sensitive sebaceous gland.