EFFECTS OF EPSILON-AMINOCAPROIC ACID ON THE TUBERCULIN REACTION IN MAN

[摘要] Previous reports that local injection of EACA can attenuate the tuberculin reaction were verified. Further study suggests that this effect is at least in part due to the fact that EACA is a whealing agent. Its inhibitory effect on the tuberculin reaction is mimicked by a similar wheal produced by histamine; and is exceeded by equimolar injection of lysine, which is a more potent whealing agent than EACA. An incidental observation was partial inhibition of the tuberculin reaction by local injection of chlorpheniramine or diphenhydramine.