OPTICAL AND SUBMICROSCOPIC STUDY OF EFFECT OF DOCA ON RAT AND MOUSE DERMAL CONNECTIVE TISSUE

[摘要] The steroid hormones are now known to have a histological effect on all components of connective tissue. Of the adrenal steroids, cortisone and its analogues were studied in detail due to their employment in therapy of disease. The mineralo-corticoids, while being widely used in maintaining homeostasis in certain metabolic dyscrasias, are not so well understood in relation to their effects on connective tissue components. This study reports the effect of DOCA [dihydroxycorticosterone acetate] in long term superficial and subcutaneous administration on rat and mouse dermal connective tissue. There is conclusive evidence that DOCA per se does not cause inflammation but enhances the tissue effects resultant to injury. There is marked fibroblastic proliferation, dense fibrosis and overall acceleration of the normal healing process.