THE VITAMIN, AMINO ACID AND GROWTH REQUIREMENTS OF THE GENUS MICROSPORUM

[摘要] Vit. requirements of the genus Microsporum were detd. M. audouini has a deficiency for thiamine when casein hydro-lysate is the N source observable only when repeated transfers on thiamine deficient media are made. It seems that this organism requires only minute quantities of thiamine for growth. With other N sources tested, adequate synthesis of thiamine is possible. M. audouini is autotrophic for all other vits. investigated. The strain of M. audouini isolated from a monkey does not conform to the findings of the rest of the audouini strains studied, and has many features of M. canis including a tendency to form macroconidia readily. The 3 spp. of Microsporum did not require nicotinic acid. Amino acid requirements of M. canis and M. audouini were investigated and reevaluated for M. gypseum. Hydroxyproline was a growth inhibitor for all the spp. of Microsporum. This inhibiting action could be overcome by proline, asparagine, and casein hydrolysate. The 8 growth stimulators investigated were unable to overcome the inhibiting action of hydroxyproline in the amts. used. Various substances having a growth stimulating effect on certain microorganisms, were unable to change the growth characteristics of any of the strains of microsporum studied with any of the N sources employed in this study.