POLYMORPHOUS LIGHT ERUPTION - THE EFFECT OF CHLOROQUINE PHOSPHATE IN MODIFYING REACTIONS TO ULTRA-VIOLET LIGHT

[摘要] Chloroquine phosphate has no effect on the minimal erythema response of the skin to hot quartz UV light either in normal individuals or in patients with the papular types of polymorphous light eruption. Chloroquine does not alter the skin response of normal individuals to histamine, trichophyton filtrate, or poison ivy antigen. Chloroquine will inhibit the papular response to hot quartz UV light in patients with polymorphous light eruption. These studies indicate that chloroquine produces its effect by modifying the reaction pattern of the patient with polymorphous light eruption in a manner which suppresses the abnormal but not the normal responses to UV light in the sunburn spectrum.