INVESTIGATIONS INTO THE ETIOLOGY OF DERMATITIS HERPETIFORMIS .1. THE EFFECTS OF SERUM FROM DERMATITIS HERPETIFORMIS CASES ON THE SPREADING PROPERTY OF HYALURONIDASE

[摘要] A series of tests have been carried out which show that there is a factor present in the serum of dermatitis herpetiformis, which significantly accelerates the spreading property of hyaluronidase during the first 40 minutes after the injection of this enzyme. This accelerating factor is inhibited by previous treatment with either prednisolone or dapsone. Normal serum inhibits the effect of hyaluronidase. Fluids from various blisters (from burns and dermatitis herpetiformis) were also tested but gave inconsistent results from which no conclusions could be drawn.