Merkel cell carcinoma: More deaths but still no pathway to blame

[摘要] Merkel cell carcinoma (MCC) is a neuroenclocrine skin cancer with a rising incidence (1500 U.S. cases per year) that now exceeds that of cutaneous Tcell lymphoma and a mortality (33%) exceeding that of melanoma. Despite this impact, little is known about its biology. Recent studies have shown that Ras/MAP kinase activity is absent and possibly detrimental to this cancer. This makes MCC distinct from other UV-induced skin cancers and highlights the question of what drives this malignancy.

[发布日期] 2007-09-01