ATTEMPTS TO TRANSFER ECZEMATOUS CONTACT-TYPE ALLERGY WITH WHOLE BLOOD TRANSFUSIONS

[摘要] Passive transfer of allergic eczematous contact sensitivity to DNCB (2, 4-dinitrochlorobenzene) was attempted in 7 patients. The technique used involved blood transfusions each of which contained at least one billion viable mononuclear cells from donors exquisitely sensitive to DNCB. No transfer was demonstrated. None of the recipients reacted to challenge with 0.1% DNCB. Two of the 7 recipients had positive reactions to 1% DNCB. The significance of these responses is discussed. DNCB in 1% concentrations approaches the borderline of primary irritancy. The results suggest that there may well be significant differences between tuberculin-type and contact-type eczematous sensitivity in man and also between contact-type eczematous sensitivity in man and guinea pigs.