IDIOPATHIC HYPERLIPEMIA AND PRIMARY HYPERCHOLESTEREMIC XANTHOMATOSIS .7. EFFECTS OF INTRAVENOUSLY ADMINISTERED FAT ON THE SERUM LIPIDS

[摘要] A single intravenous infusion of 500 ml of a 10% cottonseed oil or synthetic triolein emulsion was given to 9 patients with idiopathic hyperlipemia, 4 patients with primary hypercholesteremic xanthomatosis as well as to 14 control persons in order to study the rate of clearance of the added amount of neutral fat. Thirteen of the 14 control persons and all 4 patients with primary hyper-cholesteremic xanthomatosis showed complete or nearly complete clearance of the added fat within 6 hours. In contrast, 8 of the 9 patients with idiopathic hyperlipemia showed no clearance of the added fat during the first 6-8 hours after the infusion. This observation would seem to support the thesis that a delayed elimination of lipids from the blood stream exists in idiopathic hyperlipemia. It was further observed that the infusion of the emulsion consistently caused a significant lowering of the serum cholesterol in patients with idiopathic hyperlipemia and primary hypercholesteremic xanthomatosis and in control persons with levels of serum cholesterol above 300 mg/100 ml of serum. On the average, the decrease amounted to nearly 100 mg/100 ml of serum in 24 hours. Daily infusions of the emulsion for 1 week in 2 patients with primary hypercholesteremic xanthomatosis caused significant decreases in the serum cholesterol level. In 3 patients with idiopathic hyperlipemia a considerable reduction in the cholesterol and in the neutral fat took place resulting in clearing of the turbid sera.