EVALUATION OF NITROSTYRENES AS ANTIFUNGAL AGENTS .2. INVIVO EXPERIMENTS

[摘要] The compounds p-methoxy-beta-methyl-beta-nitrostyrene and beta-methyl-beta-nitrostyrene were tested for their ability to protect mice against experimental infections with Cryptococcus neoformans, Candida albicans, Histoplasma capiulatum and Blastomyces dermatitidis. Infection was prevented in some mice by incubating C. neoformans or C. albicans with the nitrostyrene for a short period in vitro before the mixture was inoculated into the animals. When the nitrostyrene was given after the challenge dose of fungi, there was no appreciable difference between treated and control groups. No detectable blood levels were observed in rabbits and mice inoculated with the nitrostyrene compounds. Although rabbit serum does not interfere with the antifungal activity of these compounds, they are inactivated by a component of whole blood.