FUNCTIONAL-ROLE OF ADHESION MOLECULES LFA-3 AND ICAM-1 ON CULTURED HUMAN EPIDERMAL LANGERHANS CELLS IN ANTIGEN-SPECIFIC T-CELL ACTIVATION

[摘要] Interaction of T-cell antigen receptors with antigen/major histocompatibility complex (MHC) molecule complexes on antigen-presenting cells(APC) leads to T-cell activation. Additional interaction between adhesion molecules on the APC and their ligands on T cells is required for optimal T-cell activation. In vitro cultured human epidermal Langerhans cells (cLC) are powerful APC that express adhesion molecules LFA-3 and ICAM-1. Both molecules on cLC serve a functional role in the generation of a T-cell response.

[发布日期] 1992-11-01

[效力级别]  Proceedings Paper