FACTORS AFFECTING THE DIFFUSION OF DRUGS FROM VEHICLES TO THE SKIN SURFACE

[摘要] A water soluble dye shows greatest diffusion to the skin surface from those vehicles which are easily miscible with sweat and maintain an aqueous skin-vehicle interface. An oil-soluble dye and vitamin A diffuse best from a non-volatile water miscible vehicle, which maintains the least hydration of the skin-vehicle interface. Salicylic acid causes the most pronounced irritative reaction in a water-in-oil emulsion.