MELANOCYTE-STIMULATING HORMONE RECEPTORS ON CULTURED GUINEA-PIG MELANOCYTES

[摘要] Guinea-pig melanocytes in mixed epidermal cell cultures bind melanocyte-stimulating hormone [MSH] in a distinct focal surface area in their perinuclear field and thus follow the same pattern previously described for Cloudman melanoma cells. The labeling index ranged from 18-34%. Pretreatment of cultures with trypsin leads to destruction of MSH receptors whereas neuraminidase has no such effect.