THE DISTRIBUTION OF STEROID IN SKIN FOLLOWING INTRAVENOUS INJECTION OR ORAL ADMINISTRATION

[摘要] Hydrocortisone free alcohol is found in the skin of the rat within five minutes of intravenous injection or oral administration of hydrocortisone sodium succinate. At every time interval after five minutes, the steroid concentrations in total skin water are higher than in the blood. Evidence is presented that more than half the steroid in the skin after intravenous injection is present in the intracellular fluid or in formed elements.