PHENOTHIAZINE PHOTOTOXICITY - EXPERIMENTAL-STUDY ON CHLORPROMAZINE AND ITS METABOLITES

[摘要] Chlorpromazine (CPZ) metabolites were studied for their phototoxic potency with the mouse tail technique. The demethylated metabolites were more phototoxic than CPZ, while CPZ sulfoxide, 7-hydroxy-CPZ and 2-chlorphenothiazine were less phototoxic. The phototoxicity of CPZ and desmethyl-CPZ preexposed to UVA was lost, while that of CPZ-sulfoxide was retained. By TLC, CPZ-sulfoxide and promazine were identified as photoproducts of CPZ; the sulfoxide was fairly stable to radiation.